منابع مشابه
Neutrophils in Atherosclerosis
Inflammation and activation of immune cells are key mechanisms in the development of atherosclerosis.1 Elegant experimental studies, typically performed in compound mutant mice susceptible to diet-induced atherosclerosis, indicate important roles for monocytes, T lymphocytes, and mast cells in lesion formation (Figure). Moreover, inflammatory pathways promote thrombosis, a late complication of ...
متن کاملEditorial Neutrophils in Atherosclerosis
Inflammation and activation of immune cells are key mechanisms in the development of atherosclerosis.1 Elegant experimental studies, typically performed in compound mutant mice susceptible to diet-induced atherosclerosis, indicate important roles for monocytes, T lymphocytes, and mast cells in lesion formation (Figure). Moreover, inflammatory pathways promote thrombosis, a late complication of ...
متن کاملMultiple roles for neutrophils in atherosclerosis.
Because of their rare detection in atherosclerotic lesions, the involvement of neutrophils in the pathophysiology of atherosclerosis has been largely denied. However, over the past couple of years, studies have provided convincing evidence for the presence of neutrophils in atherosclerotic plaques and further revealed the causal contribution of neutrophils during various stages of atheroscleros...
متن کاملNeutrophils in atherosclerosis: from mice to man.
Infiltration of leukocyte subsets is a driving force of atherosclerotic lesion growth, and during the past decade, neutrophils have received growing attention in chronic inflammatory processes, such as atherosclerosis. Equipped with various ready to be released mediators, evolved to fight invading pathogens, neutrophils may also hold key functions in affecting sterile inflammation, such as in a...
متن کاملProtective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis.
The CXC ligand (CXCL)12/CXC receptor (CXCR)4 chemokine-receptor axis controls hematopoiesis, organ development, and angiogenesis, but its role in the inflammatory pathogenesis of atherosclerosis is unknown. Here we show that interference with Cxcl12/Cxcr4 by a small-molecule antagonist, genetic Cxcr4 deficiency, or lentiviral transduction with Cxcr4 degrakine in bone marrow chimeras aggravated ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2012
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.268367